当前位置：
陈张朋，博士，研究员
邮箱：zpchen@shsmu.edu.cn;xiaopengczp@163.com
研究方向：癫痫中的神经代谢和神经免疫机制
教育经历：
2013-2018，南京大学，生命科学学院生物学系，博士
2009-2013，蚌埠yl23411永利，生命科学系，学士
工作经历：
2024.01-至今，yl23411永利，研究员
2023.07-2023.12，南京大学，副研究员
2020.12-2023.07，南京大学，助理研究员
2018.07-2020.12，南京大学，博士后
陈张朋 研究员
癫痫是一种重要的神经疾病，人群发病率约为1%。我国癫痫患者总数近1000万，其中，耐药性癫痫（drug-resistant epilepsy, DRE）患者约占30%，尚无有效的临床药物。课题组采用在体脑电记录，免疫磁珠细胞分选，双光子钙成像，光纤钙信号记录和全细胞膜片钳等神经科学领域前沿技术探究癫痫等重大脑疾病的发生发展机制，我们重点关注颞叶性癫痫和脑中风伴发癫痫症状中胶质细胞与神经元、免疫细胞与胶质细胞互作的机制（Nat Neurosci, 2023；Nat Neurosci, 2025；Neuron, in revision；Cell, in revision）。具体包括但不限于以下四方面研究内容：
1） 研究颞叶性癫痫疾病中胶质细胞和神经元互作及其与癫痫进展之间的关系，以此为突破口寻找抗癫痫治疗的全新靶点；
2） 开展癫痫脑（颞叶性癫痫和脑中风伴发的癫痫等）等重大脑疾病中外周免疫细胞和中枢神经细胞（胶质细胞）互作的机制研究；
3） 外界环境刺激会诱导癫痫发生，其机制尚未明了。我们重点关注声音和光等外界环境刺激诱导癫痫发作的神经环路机制。
4） 癫痫常伴发有认知和情绪障碍，其共病机制尚不清楚。我们拟开展癫痫共患认知障碍及情感障碍的神经机制研究。
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Zhang-Peng Chen#, Xiansen Zhao#, Suji Wang#, Ruolan Cai#, Haojie Ye, Meng-Ju Wang, Shi-Yu Peng, Wei-Xuan Xue, Yang-Xun Zhang, Wei Li, Hua Tang, Tengfei Huang, Qipeng Zhang, Liang Li, Lixia Gao, Hong Zhou, Chunhua Hang, Jing-Ning Zhu, Xinjian Li*, Xiangyu Liu*, Qifei Cong*, Chao Yan*, Microglial control of inhibitory synaptic transmission underlies neuronal network hyperexcitability. Nature Neuroscience, in press, 2025.
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Zhang-Peng Chen#*, Suji Wang#, Xiansen Zhao#, Wen Fang#, Zhengge Wang, Haojie Ye, Mengju Wang, Ling Ke, Tengfei Huang, Pin Lv, Xiaohong Jiang, Qipeng Zhang, Liang Li, Shu-Tao Xie, Jing-Ning Zhu, Chunhua Hang, Dijun Chen*, Xiangyu Liu*, Chao Yan*, Lipid-accumulated reactive astrocytes promote disease progression in epilepsy. Nature Neuroscience, 26(4):542-554, 2023.
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Zhang-Peng Chen, Chao Yan, Research Briefing: Abnormal lipid metabolism shapes astrocyte reactivity in patients with epilepsy. Nature Neuroscience, 26(4):535-536, 2023.
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Zhang-Peng Chen#, Xiao-Yang Zhang#, Shi-Yu Peng, Zhong-Qin Yang, Yan-Bo Wang, Yang-Xun Zhang, Xi Chen, Jian-Jun Wang*, Jing-Ning Zhu*, Histamine H1 receptor contributes to vestibular compensation, Journal of Neuroscience, 39(3):420-433, 2019.
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Yanbo Wang#, Zhang-Peng Chen#, Huanhuan Hu#, Jieqiong Lei#, Zhen Zhou#, Bing Yao, Li Chen, Gaoli Liang, Shoubin Zhan, Xiaoju Zhu, Fangfang Jin, Rujun Ma, Jun Zhang, Hongwei Liang, Ming Xing, Xiao-Rui Chen, Chen-Yu Zhang*, Jing-Ning Zhu*, Xi Chen* Sperm microRNAs confer depression susceptibility to offspring. Science Advances.7:eabd7605, 2021.
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Yi Wang#, Zhang-Peng Chen#, Qian-Xing Zhuang#, Xiao-Yang Zhang, Hong-Zhao Li, Jian-Jun Wang*, Jing-Ning Zhu*, Role of corticotropin-releasing factor in cerebellar motor control and ataxia, Current Biology, 27(17):2661-2669, 2017.
Dispatched by Manto M (2017): Motor control: CRF regulates coordination and gait. Current Biology, 27(17):R847-R850.
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Xin Ding#, Jin Wang#, Miaoxin Huang#, Zhang-Peng Chen#, Jing Liu, Qi-Peng Zhang, Yang Xiang, Cheng-Yu Zhang, Ke Zen*, Liang Li*. Microglial SIRPα negatively regulates synaptic elimination in pathophysiological conditions. Nature Communications, 12(1):2030, 2021.
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Chenwen Shao#, Zhang-Peng Chen#, Chao Yan* and Yong Qian*. 3D tracking of ferrous iron in the epileptic mouse brain and screening of iron homeostasis regulators with a two-photon fluorescent probe. STAR Protocols, 3(3):101522, 2022.
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Ming Hou, Suji Wang, Dandan Yu, Xinyi Lu, Xiansen Zhao, Zhang-Peng Chen*, Chao Yan* Cannabidiol prevents depressive-like behaviors through modulation of neural stem cell differentiation. Frontiers of Medicine, 16(2):227-239, 2022.
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Shuming Li*, Huan Liu, Pin Lv, Yu Yao, Liangyu Peng, Tianjiao Xia, Chao Yan, Zhengliang Ma, Zhang-Peng Chen*, Chunjie Zhao*, Xiaoping Gu*, Microglia mediate memory dysfunction via excitatory synaptic elimination in a fracture surgery mouse model. Journal of Neuroinflammation, 16;21(1):227, 2024.
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Haojie Ye#, Yuhui Wan#, Xin Wang, Suji Wang, Xiansen Zhao, Xinshi Wang, Tianfu Yu, Chao Yan*, Xin Tian*, Zhang-Peng Chen*, Xiangyu Liu*, Cannabidiol protects against neurotoxic reactive astrocytes-induced neuronal death in mouse model of epilepsy. Journal of Neurochemistry, 169(3):e70038, 2025.
