曾凡一 教授
组织胚胎学与遗传发育学系
电话：86-21-62790545
Email: fzeng@vip.163.com
研究方向：
医学遗传学和发育生物学，尤其是干细胞和哺乳动物胚胎工程等交叉领域的研究
个人简历
美国宾夕法尼亚大学临床医学和发育生物学医学/理学双博士，中国医学科学院学术咨询委员会学部委员，研究员（二级），博导。国家重大科学研究计划项目（“973”项目）首席科学家，“重大新药创制”科技重大专项首席科学家，长江学者特聘教授，国家杰青获得者，首批出生缺陷防控咨询师（高级）。现任永利官网特聘教授、永利官网医学遗传研究所所长。从事医学遗传学、发育生物学等交叉领域研究，承担国家级、省部级等重大项目十余项，在国际著名期刊《Nature》、《PNAS》等发表SCI论文100余篇。研究成果被美国《时代》周刊评为“全球十大医学突破”之一，多次入选“中国基础研究十大新闻”。获国家自然科学奖二等奖、教育部自然科学奖一等奖、首届第三世界女青年科学家奖、谈家桢生命科学奖创新奖等。担任国际干细胞组织（ISCF）秘书长及伦理委员会中国代表、中国遗传学会常务理事及人类与医学遗传专委会主委、中国细胞生物学学会干细胞生物学分会副会长、中华医学会医学遗传学分会常委兼秘书长等学术职务。
科研项目
1) 2024.12-2027.11国家重点研发计划“生育健康及妇女儿童健康保障”重点专项---遗传因素驱动的重大复杂结构畸形预后相关的多组学分子标志物研究，子课题负责人，项目编号 2024YFC2707002，项目经费200万元。
2) 2023.01-2026.12 国家自然科学基金（面上）“宫内移植产前治疗遗传性血液病小鼠的综合评估”，课题负责人，项目编号82271890，项目经费52万元。
3) 2021.10-2025.09 上海高水平地方高校创新团队“出生缺陷防控”，课题负责人，项目经费 1120万元。
4) 2019.12-2024.11 国家重点研发计划“胚层形成过程细胞分子调控机制”，子课题负责人，项目编号2019YFA0801402，项目经费740万元。
5) 2019.01-2022.12 国家自然科学基金（面上）“克隆牛重编程的表观遗传机理研究”，课题负责人，项目编号31871484，项目经费59万元。
6) 2017.09-2022.08 上海市临床重点专科项目“出生缺陷”，课题负责人，项目编号shslczdzk05705，项目经费50万元。
论文与专著
1) Zhao XY, Li W, Lv Z, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F, Zhou Q. iPS cells produce viable mice through tetraploid complementation. Nature, 2009. 461(7260): 86-90
2) Wang L, Xue Y, Shen Y, Li W, Cheng Y, Yan X, Shi W, Wang J, Gong Z, Yang G, Guo C, Zhou Y, Wang X, Zhou Q, Zeng F. Claudin 6: a novel surface marker for characterizing mouse pluripotent stem cells. Cell Res, 2012. 22(6): 1082-1085.
3) Lu D, Gong X, Fang Y, Guo X, Chen Y, Yang F, Zhao G, Ma Q, Zeng Y, Zeng F. Correction of RNA splicing defect in beta654-thalassemia mice using CRISPR/Cas9 gene-editing technology. Haematologica. 2022, 107(6):1427-1437.
4) Yang L, Huo Y, Wang M, Zhang D, Zhang T, Wu H, Rao X, Meng H, Yin S, Mei J, Zhang D, Chen X, Lv J, Liu M, Cheng Y, Guan Y, Feng B, Song G, Yi C, Liu M, Zeng F, Wang L, Li D. Engineering APOBEC3A deaminase for highly accurate and efficient base editing. Nat Chem Biol. 2024, 20(9):1176-1187.
5) Li H, Ma Q, Xue Y, Cai L, Bao L, Hong L, Zeng Y, Huang SZ, Finnell RH, Zeng F. Compound heterozygous mutation of AFG3L2 causes autosomal recessive spinocerebellar ataxia through mitochondrial impairment and MICU1 mediated Ca2+ overload. Sci China Life Sci, 2025.68(2):484-501.
6) Fan S, Guo C, Yang G, Hong L, Li H, Ma J, Zhou Y, Fan S, Xue Y, Zeng F#. GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway. J Genet Genomics. 2024 Oct
7) Liwen Bao, Yiye Zhou, Juan Shu, Hua Li, Shubin Xi, Miao Xu, Qin Cai, Xiuqin Dai, Yitao Zeng, Fanyi Zeng#. Impact of telomere length and mitochondrial DNA copy number variants on survival of newborn cloned calves. Theriogenology. 2024 Sep 1;225:1-8. doi: 10.1016/j.theriogenology.
8) Lei Yang, Yanan Huo, Man Wang, Dan Zhang, Tianai Zhang, Hao Wu, Xichen Rao, Haowei Meng, Shuming Yin, Jiale Mei, Dexin Zhang, Xi Chen, Jia Lv, Meizhen Liu, Yiyun Cheng, Yuting Guan, Bo Feng, Gaojie Song, Chengqi Yi, Mingyao Liu, Fanyi Zeng#, Liren Wang#, Dali Li#. Engineering APOBEC3A deaminase for highly accurate and efficient base editing. Nature Chemical Biology. 2024,10.1038/s41589-024-01595-4
9) Dan Lu, Xiuli Gong, Xinbing Guo, Yanwen Chen, Yiwen Zhu, Yudan Fang, Qin Cai, Miao Xu, Hua Yang, Dali Li#, Yitao Zeng, Fanyi Zeng#. Therapeutic Effects of Hematopoietic Stem Cell Derived From Gene-Edited Mice on β654-Thalassemia. Stem Cells. 2024,42(3):278-289
10) Jiahui Wu, Wenchen Shen, Qianhai Fan, Jingzhi Zhang#, Fanyi Zeng#. shRNA Targeting Lentiviral Vector Minus-Strand Product Improves the Viral Titer During Viral Packaging. Molecular Biotechnology. 2024,10.1007/s12033-023-01038-w
11) Jiahui Wu, Yuan Chen, Wenchen Shen, Jingzhi Zhang, Fanyi Zeng#. Reducing the transcriptional read-through rate of a lentiviral vector for β-thalassemia gene therapy. Journal of Gene Medicine. 2024,26(1) : e3640
12) Yanan Chi,†, Guanheng Yang†, Chuanliang Guo, Shaoqing Zhang, Lei Hong, Huixiang Tang, Xiao Sang, JieWang, Ji Ma, Yan Xue# and Fanyi Zeng# Identification of Cellular Compositions in Different Microenvironments and Their Potential Impacts on Hematopoietic Stem Cells HSCs Using Single-Cell RNA Sequencing with Systematical Confirmation. Life 2023, 13, 2157. https://doi.org/10.3390/life13112157
13) Jia-jun Qiu, Yan-na Liu, Hao Wei, Fanyi Zeng# and Jing-bin Yan#. Single-cell RNA sequencing of neural stem cells derived from human trisomic iPSCs reveals the abnormalities during neural differentiation of Down syndrome. Frontiers in Molecular Neuroscience, 16: 1137123,2023
14) Hou-Shi Ma, Xiu-Li Gong, Wen-Xiu Li, Qin Cai, Yan-Wen Chen, Xin-Bing Guo, Zhao-Rui Ren, Fanyi Zeng#, Jing-Bin Yan#. Missense mutation of c.635 T > C in CAPN3 impairs muscle injury repair in a Limb-Girdel Muscular Dystropy Model. Clinical Genetics, 103:663-671, 2023
15) Yanna Liu, Yuehua Zhang, Zhaorui Ren, Fanyi Zeng# and Jingbin Yan#. RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome. Molecules and Cells, 46(4): 219-230,2023
16) Jing-Jing Sun, Qin Cai, Miao Xu, Yan-Na Liu, Wan-Rui Li, Juan Li, Li Ma , Cheng Cai,Xiao-Hui Gong, Yi-Tao Zeng, Zhao-Rui Ren and Fanyi Zeng#. Loss of Protein Function Causing Severe Phenotypes of Female-RestrictedWieacker Wolff Syndrome due to a Novel Nonsense Mutation in the ZC4H2 Gene. Genes. 13(9), 1558,2022.8
17) Guanghui Liu, Guanheng Yang, Guijun Zhao, Chuanliang Guo, Yitao Zeng, Yan Xue#, Fanyi Zeng#. Spatial transcriptomic profiling to identify mesoderm progenitors with precision genomic screening and functional confirmation. Cell Prolif. e13298, 2022.7
18) Shao-Qing Zhang, Xiu-Li Gong, Yi-Ye Zhou, Qingwen Ma, Qin Cai, Guan-Heng Yang, Xin-Bing Guo, Yan-Wen Chen, Miao Xu, Yi-Wen Zhu, Yitao Zeng, Fanyi Zeng#. Maternal Prkce expression in mature oocytes is critical for the first cleavage facilitating maternal-to-zygotic transition in mouse early embryos. Cell Prolif . 18;e13231, 2022.5
19) Dan Lu, Xiuli Gong, Yudan Fang, Xinbing Guo, Yanwen Chen, Fan Yang, Guijun Zhao, Qingwen Ma, Yitao Zeng, Fanyi Zeng#. Correction of RNA splicing defect in beta654-thalassemia mice using CRISPR/Cas9 gene-editing technology. Haematologica. 107(6):1427-1437. 2022 Jun 1.
20) Jiajun Qiu, Xiao Ma, Fanyi Zeng#, Jingbin Yan#. RNA editing regulates IncRNA splicing in human early embryo development. PLOS Computational Biology. 17(12): e 1009630,2021.12
